Make sure that you are in good general health before leaving. Have even minor things that are bothering you checked out as they may be aggravated by traveling. Have a last check-up with the dentist, the optometrist, etc.
From your physician, get a prescription for enough of your regular medication that will ideally last you for the whole trip, expiry date permitting. If you are bringing large quantities of drugs, have your doctor issue a specific authorization letter to avoid problems at border crossings.
Have your travel doctor assess your need for medication against malaria as well as review your vaccinations and, if necessary, prepare a vaccination schedule for you.